With Age comes Wisdom…er, Mutations.

Although older mothers are at higher risk for complications such as diabetes during pregnancy and are more likely to have children with chromosomal disorders such as Down syndrome, the study found that practically all of the new mutations detected in children came from the father.

To me, children of the atom: A scientific study suggests that progeny of older men are more prone to mutations like autism, schizophrenia, telekinesis, and whatnot. “A man aged 29.7 at the time he fathered a child contributed 63 new mutations on average to his offspring, the authors found, and a man aged 46.2 contributed 126 mutations — a doubling, the authors calculated.” My biological clock is ticking like this…

Akin is the New Normal.


So, Todd Akin. I must say, it’s heartening to see some of the Taliban-like tendencies of today’s GOP finally drawing condemnation in the culture at large. But the thing is, what Rep. Akin said is very much within the mainstream of his party. This was not a one-off event: They actually believe this tripe, and they’re constantly voting like The Handmaid’s Tale was meant to be aspirational.

In their very first month back in power, Paul Ryan, Akin and the gang — 225 Members, in fact — were trying to define rape down — “House Speaker John Boehner (R-Ohio) has dubbed [it] a top priority in the new Congress.” — and that bill passed the House(!)

Yes, today’s Democrats have their own serious problems — our leaders prostrate themselves before the phantom deficit gods, look the other way on Wall Street malfeasance, and have been actively terrible on the civil liberties front, and our policy playbook (individual mandate, cap-and-trade) has too often been cribbed from the Republicans of the ’90s. But it’s a difference in kind, not in degree. Akin is not an aberration in the GOP — He’s the new normal. Not that anyone who comes around here still does this sort of thing, but if you vote Republican, have no illusions about what you are doing: Ayn Rand and Akinism is basically what you’re voting for. Seriously, these guys are cray-cray.

(By the way, the great facehugger pic above is from From Talking to Doctors — worth checking out.)

It’s a Sick World Sometimes.


Maybe he’s retiring, maybe it’s just a sabbatical. (And, either way, he still has Haywire in the can and Magic Mike, The Man From U.N.C.L.E., and a Liberace biopic on his plate, not to mention second unit work on The Hunger Games.) Still, as the crisp, dark, and intelligent Contagion once again makes clear, Hollywood will lose one of its most interesting working directors when Steven Soderbergh decides to hang up the clapperboard.

Less adventurous and more satisfying in its storytelling than Soderbergh’s last major film, 2009’s The Informant!, Contagion basically applies the Traffic technique of several separate, loosely interweaving tales told around the globe (albeit this time with a more subdued color palette) to spin a harrowing chronicle of a possible pandemic. The main reason the film works so well is because Contagion is actually not the end-of-times pestilence thriller the (spoilerish) trailers make it out to be. Rather, and much like David Fincher’s Zodiac, it’s mainly a smart, well-told procedural, and it’s the grounded, matter-of-factness of Contagion that ultimately makes it so frightening.

Contagion telegraphs its unsentimental, take-no-prisoners approach to the story in the first five minutes, when, after returning home to Minneapolis from a business trip to Macau (and a brief layover in Chicago), Gwyneth Paltrow starts having trouble breathing and [minor spoiler] promptly drops dead. Soon, her family (including a low-key, earnest Matt Damon) are in quarantine, and the CDC Director in Atlanta (Lawrence Fishburne) has dispatched an epidemiologist (Kate Winslet) to coordinate with local officials on plans for a possible outbreak. (FWIW, the Minnesota Department of Health is not amused with the film.) But, unfortunately for the world, the barn door is already open: This new MERS-1 virus — part-bat, part-pig — has already been unleashed, and not just in Minneapolis, but in cities all over. (Turns out, Oceans 14 in Macau was a terrible idea.)

As the situation worsens around the world, we start following more individuals on the frontlines in various locales: A CDC researcher (Jennifer Ehle) working to find a cure for this new plague. An academic biologist (Elliot Gould) trying to isolate the virus in San Francisco. A WHO official (Marion Cotillard) and Chinese doctor (Chin Han) looking to discover who was Patient Zero in Macau. Two homeland security suits (Brian Cranston and Enrico Colatoni) sent to determine if this is the work of the terr’ists. A blogger (Jude Law) firmly convinced of government conspiracies and homeopathic wonders. And all the while, even as secrets pass from person to person and fear mutates into panic, the virus continues to spread. Ain’t no Patrick Dempsey monkey gonna solve this one, I’m afraid.

There’re plenty of stars and recognizable faces flitting about this story — some have more to do than others. (The Cotillard subplot seemed a bit unnecessary to me, to be honest, and the Jude Law one is basically just an extended screw-you to the vaccines-cause-autism crowd.) But, as I said, Contagion‘s killer app is its versimilitude. The movie never talks down to its audience, or has its scientists repeating expository information over and over again. (For example, it explains once what a “R-naught” is and assumes you can keep up from there.) It doesn’t have scientists (or Matt Damon, for that matter) running around trying to catch infected monkeys with helicopters — The excitement mostly comes from watching scientists and bureaucrats do their job well. And I liked the fact that, even though no one is safe here, Contagion doesn’t feature some kind of sci-fi-ish, humanity-obliterating virus. It’s a nasty bug with, iirc, a 25% fatality rate — In other words, a more virulent version of the 1918 influenza epidemic — making the story that much more plausible, and scary.

Speaking of scary, I should say that, back in the real world, I’m a pretty sanguine sort about germs, and so I found Contagion more unsettling than anything else. But if you’re at all of the germophobe persuasion, hoo boy — You’re going to have a tough time at this one. From infecteds hacking up a lung on a public bus, to waiters wiping down bar glasses with a dirty rag, to people endlessly and unconsciously touching rails, bannisters, buttons, and each other, Soderbergh does a great job here of intimating that human beings inadvertently leave a slime trail of germy death wherever we go — not the least in movie theaters, exactly like the one you’re sitting in. Point being, [cough, cough], OCD-ish folks will probably want to Netflix this one, instead.

World of Enzymecraft | Taming the Dragon.


Games provide a framework for bringing together the strengths of computers and humans. The results in this week’s paper show that gaming, science and computation can be combined to make advances that were not possible before.” Score one for spatial reasoning: Using the game Foldit, online gamers manage to decipher a enzyme structure that has eluded scientists for a decade — in three weeks. “Cracking the enzyme ‘provides new insights for the design of antiretroviral drugs’, says the study, referring to the medication to keep people with the human immunodeficiency virus (HIV) alive.

On the subject of HIV, it looks like the enemy of our enemy is our friend: In a stunning feat of gene therapy, scientists have used a disabled version of HIV to successfully defeat leukemia. “Mr. Ludwig’s doctors have not claimed that he is cured — it is too soon to tell — nor have they declared victory over leukemia on the basis of this experiment, which involved only three patients…But scientists say [this] may signify a turning point in the long struggle to develop effective gene therapies against cancer…In essence, the team is using gene therapy to accomplish something that researchers have hoped to do for decades: train a person’s own immune system to kill cancer cells.

Deregulating Rape.

With this legislation, which was introduced last week by Rep. Chris Smith (R-N.J.), Republicans propose that the rape exemption be limited to ‘forcible rape.’ This would rule out federal assistance for abortions in many rape cases, including instances of statutory rape, many of which are non-forcible. For example: If a 13-year-old girl is impregnated by a 24-year-old adult, she would no longer qualify to have Medicaid pay for an abortion.

On the principle that, as per MLK, “in the end, we will remember not the words of our enemies, but the silence of our friends,” I post more often here these days about issues I have with our own, ostensibly-lefty party. But, as Dangerous Meta reminds me: Just in case anyone forgot how crazy the Republicans are these days, the GOP Congress has, for pro-life purposes, actually fashioned a bill that defines rape down. “House Speaker John Boehner (R-Ohio) has dubbed [it] a top priority in the new Congress.” There are no words.

We’re No. 50!

On the eve of the State of the Union — Win the Future! — the wags at Pleated Jeans compile a handy map of what each state desperately needs to work on. (By way of Blackpepper and Webgoddess.) “Whether it’s a fat population, high rate of STDs or excessive tax rate, it turns out that every state ranks dead last in at least one unsavory category. Check out the map (click image to enlarge) to see what your state is the worst at, then review additional stats and references after the jump.

We’ll see how smart you are when the K-9 comes…


Chaser proved to be a diligent student. Unlike human children, she seems to love her drills and tests and is always asking for more. ‘She still demands four to five hours a day,” Dr. Pilley said. “I’m 82, and I have to go to bed to get away from her.‘”

The NYT tells the tale of Chaser, a border collie with a vocabulary of over 1000 words now. “Dr. Pilley said that most border collies, with special training, ‘could be pretty close to where Chaser is.’…Dr. Horowitz agreed: ‘It is not necessarily Chaser or Rico who is exceptional; it is the attention that is lavished on them,” she said.’” (Sorry, Berk…At least I taught you bacon and tacos — you know, the important stuff.)

Guinness for Brains.


Drinking alcohol was ‘unintentional, accidental, and haphazard until about 10,000 years ago,’ says Satoshi Kanazawaat at Psychology Today. Smart people are generally early adopters and, in the context of human history, ‘the substance [alcohol] and the method of consumption are both evolutionarily novel.

Two new studies find a correlation between intelligence and a thirst for alcohol. Hey, I buy it – Thank you, science, for lending support to my vices! And, as Bogey said, “The problem with the world is that everyone is a few drinks behind.

I was so much older then…

On the global measure, people start out at age 18 feeling pretty good about themselves, and then, apparently, life begins to throw curve balls. They feel worse and worse until they hit 50. At that point, there is a sharp reversal, and people keep getting happier as they age. By the time they are 85, they are even more satisfied with themselves than they were at 18.” Via the NYT, a new study finds older people tend to be the happiest among us.

“‘It could be that there are environmental changes,’ said Arthur A. Stone, the lead author of a new study based on the survey, ‘or it could be psychological changes about the way we view the world, or it could even be biological — for example brain chemistry or endocrine changes.’” My guess, from where I sit at 35 — perspective, a.k.a. wisdom. You don’t live to 85 by sweating the small stuff, and by then you probably have a pretty good sense of how things tend to shake out anyway.

A Cure for Cancer? Well, a vaccine, anyway.

‘We believe this vaccine will someday be used to prevent breast cancer in adult women in the same way that vaccines prevent polio and measles in children,’ Vincent Tuohy, Ph.D., the study’s principal investigator and an immunologist at the Lerner Institute, told WOIO. ‘If it works in humans the way it works in mice, this will be monumental. We could eliminate breast cancer,’ he added.

Some good news for the day: Scientists at the Cleveland Clinic believe they may have zeroed in on a vaccine for breast cancer. “The key, Tuohy said, is to find a target within the tumor that isn’t typically found in a healthy person. In the case of breast cancer, he and his team targeted a-lactalbumin, a protein found in the majority of breast cancers, but not in healthy women, except during lactation. Therefore, the vaccine can rev up a woman’s immune system to target a-lactalbumin, stopping tumor formation without damaging healthy breast tissue.